N-(4-Methylphenylsulfonyl)-3-nitrobenzamide
نویسندگان
چکیده
منابع مشابه
Enzymatic mechanism of the tumoricidal action of 4-iodo-3-nitrobenzamide.
Activation of the prodrug 4-iodo-3-nitrobenzamide critically depends on the cellular reducing system specific to cancer cells. In non-malignant cells, reduction of this prodrug to the non-toxic amine occurs by the flavoprotein of complex?I of mitochondria receiving Mg2+-ATP-dependent reducing equivalents from NADH to NADPH via pyridine nucleotide transhydrogenation. This hydride transfer is def...
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In the title compound, C(21)H(19)N(3)O(4), the central benzene ring makes dihedral angles of 78.54 (6) and 75.30 (6)° with the pyridine and 3-methoxy-phenyl rings, respectively. An intra-molecular N-H⋯N interaction occurs, generating an S(?). The crystal packing shows inter-molecular N-H⋯O hydrogen-bonding inter-actions between the N-H groups and the O atoms of the 3-methoxy-phenyl ring and the...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section E Structure Reports Online
سال: 2014
ISSN: 1600-5368
DOI: 10.1107/s1600536814001317